4/7/2023 0 Comments Mpv car meaningIn addition, Pearson correlation test was used in order to determine the relationship between the platelet count as well as MPV and ESR and CRP. The platelet counts and MPV of admission and recovery times were compared using paired t‐test. Statistical analyses were performed using the SPSS statistical software (v. Proper data collection form was designed to record the patients’ demographic information, contact number, residential place, disease name, and the paraclinical findings. ESR was also measured using ESR auto analyzer (Electa, Italy). Serum level of CRP was calculated by using semiquantitative agglutination on latex kite (Human Company, Germany). Platelet parameters, including platelet count and MPV, were measured automatically using Sysmex k 1000 (Sysmex Inc., Japan). The study was approved by the Ethics Committee of Shiraz University of Medical Sciences, Shiraz, Iran. This analytic, cross‐sectional study was conducted on 100 children (51 male and 49 female) with infectious and inflammatory diseases admitted in pediatric immunology and infectious ward of Nemazee Hospital, Shiraz University of Medical Science, Shiraz, Iran.Īll the patients who had been diagnosed with any infectious or inflammatory disease were enrolled into the study.Īll the eligible patients were included after taking consents from their parents or their legal guardians. Considering the role the platelets play in the pathophysiology of infection and inflammation and the fact that platelet parameters are very easy and simple lab procedures to perform, by collecting more information of how these markers change, it has been tried to show the clinical importance of these changes that can be considered as the criteria to assess the disease activity and response to treatment. The present study aims to assess the changes in platelet parameters, such as platelet count and MPV, and the relation between each of those markers with ESR and CRP in infectious and inflammatory diseases. on the cohort of patients with intestine inflammation showed a significant correlation between MPV reduction and some other acute response phase markers, such as CRP and ESR and, as a result, MPV can be used as an independent marker in assessment of disease activity 8. From all the previous studies, it can be concluded that in case of an active infection or inflammation (apart from the acute sepsis), there is an increase in platelet count, but a decrease in MPV 7. Since then, some other studies have been conducted on platelet parameters changes during infectious and inflammatory processes. Nevertheless, a primary increase in MPV along with thrombocytopenia could occur in acute sepsis 6. In 1983, Robbins and Barnard performed a cohort study and found out that there were at least two different patterns in changes of platelet parameters in response to infection: increase in platelet count and decrease in mean platelet volume (MPV). Nowadays, platelet count as well as platelets size can be easily measured by automatic counter devices however, only a few studies have been done with regard to the clinical importance of using platelet markers fluctuations as an indicator of “acute phase response” for assessment of disease activity and response to the treatment. This increase in platelets can reflect the bone marrow cells activity in response to the inflammation phase interleukins, such as IL‐1 and IL‐6 4, 5. Platelets, as another part of the natural immune system, can be elevated in response to “acute phase reaction” during the inflammation process. ESR and CRP are widely requested by the physicians in order to estimate the presence and severity of infectious and inflammatory diseases. Elevated erythrocyte sedimentation rate (ESR) is another marker of inflammatory reactions 3. This response can be associated with the symptoms, including fever, fatigue, and anorexia 1, 2.Ĭ‐reactive protein (CRP) is one of the acute phase reaction proteins, which is synthesized from liver and increases during inflammatory reactions. In case of inflammatory stimulations, the first reaction step of this system is creating a local inflammation, in which the intrinsic immunity cells are called to be in the inflammation area. Because of the importance of these cases, some kinds of diagnostic examinations are always undertaken. Infectious and inflammatory diseases are the most common diseases that delay the diagnosis and inadequate treatment in these cases can increase the mortality and morbidity and also cause a lot of costs for national health services.
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